The Rock Lab at the University of Chicago

We study the remarkable protein machines that drive biological motion, cell morphology, and the organization of subcellular structures.

Our work combines tools from single molecule biophysics, structural biology, and cell biology. We build complex motile systems from individual parts, measure the forces that they generate, and identify the structural basis for their regulation. We also map biological motions to discover new self-organization rules in a range of cell types. Our discoveries guide efforts to reprogram motility within the cell.